No Such Thing As a Resting Macrophage

Just sat through a seminar by David Russell (Cornell Univ.) titled: Mycobacterium: Life and death in the phagosome." It was, in my opinion, a paradigm shifting seminar concerning the real time inner workings of the macrophage phagosome. His lab has developed techniques to measure the kinetics of phagosome maturation. Every immunologist needs to hear and/or read about this work. The 'activated macrophage' phagosome probably works just the opposite from how most immunologist think it does. Very soon immunology textbook explanations on macrophage phagosome function will need to be re-written. Here is a reference to part of the work.